The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2023

Filed:

Jun. 15, 2017
Applicants:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Emory University, Atlanta, GA (US);

Inventors:

Howard Y. Chang, Stanford, CA (US);

Ye Grace Chen, Stanford, CA (US);

Bali Pulendran, Stanford, CA (US);

Sudhir Kasturi, Atlanta, GA (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/67 (2006.01); A61K 39/39 (2006.01); C12N 15/117 (2010.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/67 (2013.01); A61K 39/39 (2013.01); C12N 15/117 (2013.01); A61K 2039/55555 (2013.01); C12N 2310/17 (2013.01); C12N 2310/532 (2013.01);
Abstract

Compositions and methods of modulating an innate immune response with circular RNAs are disclosed. In particular, the disclosure relates to methods for modifying an RNA by circularization and the use of circular RNAs generated with exogenous introns to stimulate an innate immune response or circular RNAs generated with endogenous introns to prevent immune recognition of foreign RNA.


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