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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11813352 B1

PDFFull Text
Date of Patent:
Nov. 14, 2023

Filed:

Nov. 20, 2018

Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response

Applicant:

North Carolina State University, Raleigh, NC (US);

Inventors:

Zhen Gu, Los Angeles, CA (US);

Jinqiang Wang, Raleigh, NC (US);

Assignee:

North Carolina State University, Raleigh, NC (US);

Attorney:

Jenkins, Taylor & Hunt P.A.,

Primary Examiner:

Melissa S Mercier

Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 47/58 (2017.01); A61P 3/10 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 38/28 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0021 (2013.01); A61K 9/5026 (2013.01); A61K 9/5138 (2013.01); A61K 38/28 (2013.01); A61K 47/58 (2017.08); A61P 3/10 (2018.01);
Abstract

A composition comprising a glucose-responsive charge-switchable polymer is described. In the absence of glucose or under normoglycemic conditions, the positively charged polymer can be complexed with negatively charged therapeutic agents, such as insulin. Under hyperglycemic conditions, the positive charge of the polymer is reduced, and the polymer/therapeutic agent complex can disassemble, allowing the therapeutic agent to be released. Pharmaceutical compositions, nanoparticles, and microneedle arrays of the polymer and/or polymer/therapeutic agent complex and methods of treating diabetes are also described.

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Gu, Zhen. (2023). Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response (U.S. Patent No. 11813352). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11813352

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