The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2023
Filed:
Jun. 07, 2019
Applicant:
Salk Institute for Biological Studies, La Jolla, CA (US);
Inventors:
Clodagh O'Shea, San Diego, CA (US);
Colin Powers, San Diego, CA (US);
Lei Zhang, San Diego, CA (US);
Assignee:
Salk Institute for Biological Studies, La Jolla, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 7/00 (2006.01); C12Q 1/66 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61P 35/00 (2018.01); C12N 7/00 (2013.01); C12Q 1/66 (2013.01); C12N 2799/022 (2013.01); C12Y 113/12007 (2013.01); G01N 2800/7028 (2013.01);
Abstract
Synthetic adenoviruses with liver detargeting mutations and expressing an adenovirus type 34 (Ad34) fiber protein, or a chimeric fiber protein with an Ad34 knob domain, are described. The synthetic adenoviruses traffic to sites of tumors. Use of the synthetic adenoviruses for delivering diagnostic or therapeutic transgenes to tumors are also described.