The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2023
Filed:
Feb. 12, 2018
Applicant:
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, CN;
Inventors:
Huifeng Jiang, Tianjin, CN;
Xiaoyun Lu, Tianjin, CN;
Yuwan Liu, Tianjin, CN;
Yiqun Yang, Tianjin, CN;
Lina Lu, Tianjin, CN;
Sheng Yang, Tianjin, CN;
Junran Gou, Tianjin, CN;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); C12P 7/24 (2006.01); C12P 7/28 (2006.01); C12P 9/00 (2006.01); C12P 19/32 (2006.01);
U.S. Cl.
CPC ...
C12N 9/88 (2013.01); C12P 7/24 (2013.01); C12P 7/28 (2013.01); C12P 9/00 (2013.01); C12P 19/32 (2013.01); C12Y 401/01007 (2013.01);
Abstract
An enzyme synthesizes hydroxyl acetaldehyde and/or 1,3-dihydroxyacetone by catalyzing formaldehyde. Site-directed mutation of benzoylformate decarboxylase (BFD) creates a mutant of the enzyme, which can polymerize the formaldehyde, A phosphoketalose (F/XPK) generates acetyl phosphoric acid from the hydroxyl acetaldehyde or 1,3-dihydroxyacetone (DHA). Combination with phosphotransacetylase (Pta) provides a route from the formaldehyde to acetyl coenzyme A in three steps.