The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
Dec. 27, 2018
Applicant:
Immunogen, Inc., Waltham, MA (US);
Inventors:
Michael Louis Miller, Framingham, MA (US);
Manami Shizuka, Belmont, MA (US);
Ravi V. J. Chari, Newton, MA (US);
Assignee:
IMMUNOGEN, INC., Waltham, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 243/10 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 47/6869 (2017.08); A61P 35/00 (2018.01);
Abstract
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I), (II) and (III). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.