The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Oct. 02, 2018
Fred Hutchinson Cancer Center, Seattle, WA (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Jarrod Dudakov, Seattle, WA (US);
Marcel van den Brink, New York, NY (US);
Enrico Velardi, New York, NY (US);
Hans-Peter Kiem, Seattle, WA (US);
Stefan Radtke, Seattle, WA (US);
Scott James, New York, NY (US);
Fred Hutchinson Cancer Center, Seattle, WA (US);
Abstract
The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.