The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
May. 14, 2018
The Jackson Laboratory, Bar Harbor, ME (US);
University of Massachusetts, Boston, MA (US);
Michael A. Brehm, Dudley, MA (US);
Michael V. Wiles, Mount Desert, ME (US);
Dale L. Greiner, Hubbardston, MA (US);
Leonard D. Shultz, Bar Harbor, ME (US);
The Jackson Laboratory, Bar Harbor, ME (US);
University of Massachusetts, Boston, MA (US);
Abstract
A NOD.Cg-PrkdcH2rg/SzJ.(NOD-scid-IL2rγ, NSG) mouse which is genetically modified such that the en NSG mouse lacks functional major histocompatibility complex I (MHC I) and lacks functional major histocompatibility complex II (MHC II) is provided according to aspects of the present, invention. According to specific aspects the genetically modified NSG mouse, is a NOD.Cg-PrkdcH2-K1H2-Ab1H2-D1H2rg/SzJ (NSG-KD)(IA)) mouse, NSG-RIP-DTR (KD)(IA) mouse, or a NOD.Cg-B2mPrKdcH2H2rg/SzJ (NSG-B2M(IA IE)) mouse. Human, immune cells and/or human: tumor cells are administered to a genetically modified immunodeficient mouse according to aspects described herein and assays of one or more test substances can be performed using the provided mice.