The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
Feb. 21, 2020
Obi Pharma, Inc., Taipei, TW;
Cheng-Der Tony Yu, Taipei, TW;
Yih-Huang Hsieh, Taipei, TW;
Shu-Yi Lin, Taipei, TW;
Chin-Sheng Chao, Taipei, TW;
Yin-Cheng Hsieh, Taipei, TW;
Ming-Tain Lai, Taipei, TW;
OBI PHARMA, INC., Taipei, TW;
Abstract
A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The 'R-form' compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the 'S-form' compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.