The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2023
Filed:
Oct. 31, 2018
The Broad Institute, Inc., Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
The Regents of the University of California, Oakland, CA (US);
Amit Choudhary, Boston, MA (US);
Kurt Cox, Cambridge, MA (US);
Basudeb Maji, Cambridge, MA (US);
Peng Wu, Boston, MA (US);
Hari Subramanian, Oakland, CA (US);
Elisa Franco, Oakland, CA (US);
Abstract
The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.