The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Jan. 31, 2017
Applicant:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Inventors:
Siyuan Tan, Lexington, MA (US);
Tongyao Liu, Lexington, MA (US);
Assignee:
BIOVERATIV THERAPEUTICS INC., Waltham, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/00 (2006.01); C12N 15/63 (2006.01); A61K 31/70 (2006.01); C07K 14/755 (2006.01); A61K 48/00 (2006.01); C12N 15/86 (2006.01); A61P 7/04 (2006.01); C12N 7/00 (2006.01); A01K 67/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); A61K 48/005 (2013.01); A61K 48/0016 (2013.01); A61P 7/04 (2018.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/16043 (2013.01); C12N 2800/22 (2013.01);
Abstract
The present disclosure provides codon optimized Factor VIII sequences, vectors, and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides. The present disclosure also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized Factor VIII nucleic acid sequence or the polypeptide encoded thereby.