The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Mar. 27, 2017
Takeda Pharmaceutical Company Limited, Osaka, JP;
Kentaro Iwata, Kanagawa, JP;
Masahiro Mizuno, Osaka, JP;
Kazuhiro Maeda, Osaka, JP;
Tsuneo Yasuma, Osaka, JP;
Misaki Homma, Kanagawa, JP;
Yuya Oguro, Kanagawa, JP;
Naohiro Taya, Kanagawa, JP;
Lei Zhu, Bedford, MA (US);
John Daniel Bailey, Cambridge, MA (US);
Marianne Langston, Cambridge, MA (US);
Siddhesh Dinanath Patil, Cambridge, MA (US);
Shruti Gour, Watertown, MA (US);
Lilly Roy, Boston, MA (US);
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I)·0.5HO; processes for preparing crystalline forms of Compound 1 and/or tautomers thereof; pharmaceutical compositions comprising the crystalline forms; methods of inhibiting a cell division cycle 7 in a mammal comprising administering the crystalline forms; and methods of treating a cell division cycle 7 mediated cancer in a mammal comprising administering the crystalline forms or a pharmaceutical composition comprising the crystalline forms.