The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 22, 2023

Filed:

Sep. 10, 2020
Applicant:

Fei Company, Hillsboro, OR (US);

Inventors:

Alex De Marco, Melbourne, AU;

Sergey Gorelick, Cheltenham, AU;

Chad Rue, Portland, OR (US);

Joseph Christian, Beaverton, OR (US);

Kenny Mani, Beaverton, OR (US);

Steven Randolph, Portland, OR (US);

Matthias Langhorst, Hameln, DE;

Assignee:

FEI Company, Hillsboro, OR (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
H01J 37/32 (2006.01); H01J 49/00 (2006.01); G01N 1/32 (2006.01);
U.S. Cl.
CPC ...
H01J 49/0027 (2013.01); G01N 1/32 (2013.01); H01J 37/32009 (2013.01); H01J 2237/0807 (2013.01); H01J 2237/31745 (2013.01); H01J 2237/31749 (2013.01);
Abstract

The invention relates to a method, a device and a system for the treatment of biological frozen samples using plasma focused ion beams (FIB). The samples can then be used for mass spectrometry (MS), genomics, such as gene sequencing analysis or next generation sequencing (NGS) analysis, and proteomics. The present invention particularly relates to a method of treatment of at least one biological sample. This method is particularly used for high performance microscopy, proteomics analytics, sequencing, such as NGS etc. According to the present invention the method comprises the steps of providing at least one biological sample in frozen form. The milling treats at least one part of the sample by a plasma ion beam comprising at least one of an Oand/or a Xeplasma.


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