The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2023
Filed:
Feb. 12, 2021
Immunogen, Inc., Waltham, MA (US);
Nathan Elliott Fishkin, Weymouth, MA (US);
Daniel J. Tavares, Natick, MA (US);
Lingyun Rui, Weston, MA (US);
Luke B. Harris, Boston, MA (US);
Manami Shizuka, Belmont, MA (US);
Michael Louis Miller, Framingham, MA (US);
Ravi V. J. Chari, Newton, MA (US);
IMMUNOGEN, INC., Waltham, MA (US);
Abstract
The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.