The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2023
Filed:
May. 20, 2019
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US);
Carl H. June, Merion Station, PA (US);
Ellen Pure, Bryn Mawr, PA (US);
Liang-Chuan Wang, Philadelphia, PA (US);
Steven Albelda, Philadelphia, PA (US);
John Scholler, Penn Valley, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US);
Abstract
The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.