The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2023
Filed:
Mar. 13, 2022
University of South Carolina, Columbia, SC (US);
Ozgur Sahin, Lexington, SC (US);
Campbell McInnes, Irmo, SC (US);
Ozge Saatci, Columbia, SC (US);
Chad Beneker, Irmo, SC (US);
Abdol-Hossein Rezaeian, Lexington, SC (US);
Metin Cetin, Columbia, SC (US);
University of South Carolina, Columbia, SC (US);
Abstract
Described herein are novel compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 μM, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.