The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2023
Filed:
Nov. 24, 2020
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Martin Duplessis, Somerville, MA (US);
Georg Jaeschke, Basel, CH;
Bernd Kuhn, Reinach BL, CH;
Kiel Lazarski, Boston, MA (US);
Yanke Liang, Belmont, MA (US);
Yvonne Alice Nagel, Basel, CH;
Antonio Ricci, Biel-Benken, CH;
Daniel Rueher, Raedersdorf, FR;
Sandra Steiner, Sursee, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61P 35/00 (2006.01); A61K 9/48 (2006.01); A61K 9/20 (2006.01); A61K 9/02 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61K 9/009 (2013.01); A61K 9/0019 (2013.01); A61K 9/02 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/485 (2013.01); A61K 9/4825 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 9/4875 (2013.01); A61P 35/00 (2018.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01);
Abstract
The present invention provides compounds which are selective allosteric inhibitors of T790M and C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.