The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 04, 2023

Filed:

May. 07, 2021
Applicant:

California Institute of Technology, Pasadena, CA (US);

Inventors:

Samson Chen, Pasadena, CA (US);

Axel Scherer, Barnard, VT (US);

Dvin Adalian, Pasadena, CA (US);

Peter Petillo, Pasadena, CA (US);

Muhammad Musab Jilani, Pasadena, CA (US);

Xiomara L. Madero, Pasadena, CA (US);

Deepan Kishore Kumar, Pasadena, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/145 (2006.01); C12N 11/02 (2006.01); A61B 5/1486 (2006.01); C12N 9/02 (2006.01); A61B 5/1459 (2006.01); G01N 27/327 (2006.01); C12N 11/14 (2006.01);
U.S. Cl.
CPC ...
A61B 5/14865 (2013.01); A61B 5/1459 (2013.01); A61B 5/14532 (2013.01); C12N 9/0004 (2013.01); C12N 11/02 (2013.01); C12N 11/14 (2013.01); G01N 27/3272 (2013.01); C12Y 101/01001 (2013.01); C12Y 101/0301 (2013.01); C12Y 101/0302 (2013.01); C12Y 101/03003 (2013.01); C12Y 101/0303 (2013.01); C12Y 101/0304 (2013.01); C12Y 101/03005 (2013.01); C12Y 101/03007 (2013.01); C12Y 101/03008 (2013.01); C12Y 101/03011 (2013.01); C12Y 101/03012 (2013.01); C12Y 101/03015 (2013.01); C12Y 101/03016 (2013.01); C12Y 101/03018 (2013.01); C12Y 101/03019 (2013.01); C12Y 101/03023 (2013.01); C12Y 101/03027 (2013.01); C12Y 101/03029 (2013.01); C12Y 101/03037 (2013.01); C12Y 101/03038 (2013.01); C12Y 101/03041 (2013.01);
Abstract

A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.


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