The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2023
Filed:
Jun. 06, 2018
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Miguel Sena Esteves, Westford, MA (US);
Guangping Gao, Westborough, MA (US);
Michael R. Green, Boylston, MA (US);
Dan Wang, Belchertown, MA (US);
Tessa Mercedes Simone, Worcester, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/4702 (2013.01); C07K 2319/41 (2013.01); C12N 2310/141 (2013.01); C12N 2330/10 (2013.01); C12N 2750/14143 (2013.01);
Abstract
In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.