The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2023
Filed:
Sep. 13, 2019
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Jianghong Rao, Palo Alto, CA (US);
Yunfeng Cheng, Stanford, CA (US);
Min Chen, Stanford, CA (US);
Jianghang Xie, Fremont, CA (US);
Zixin Chen, Stanford, CA (US);
The Board of Trustees of Leland Stanford Junior University, Stanford, CA (US);
Abstract
Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.