The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2023
Filed:
Dec. 02, 2021
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Jae-Hyuck Shim, Westborough, MA (US);
Guangping Gao, Westborough, MA (US);
Jun Xie, Shrewsbury, MA (US);
Yeon-Suk Yang, Westborough, MA (US);
Jung min Kim, Worcester, MA (US);
Sachin Chaugule, Shrewsbury, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61P 19/08 (2006.01); A61K 38/45 (2006.01); A61K 48/00 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 38/45 (2013.01); A61K 48/0066 (2013.01); A61P 19/08 (2018.01); C12N 9/22 (2013.01); C12N 15/111 (2013.01); C12Y 207/1103 (2013.01); C12N 2310/141 (2013.01); C12N 2310/20 (2017.05); C12N 2320/34 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/008 (2013.01);
Abstract
In some aspects, the disclosure relates to compositions and methods for treating fibrodysplasia ossificans progressiva (FOP) in a subject. In some aspects, the disclosure provides isolated nucleic acids, and vectors such as rAAV vectors, configured to express transgenes that inhibit (e.g., decrease) expression of mutated AVCR1 gene in muscle cells or connective tissues.