The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2023
Filed:
Apr. 18, 2016
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Michael Elowitz, Los Angeles, CA (US);
Lacramioara Bintu, Pasadena, CA (US);
John Yong, Pasadena, CA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/62 (2006.01); C12Q 1/68 (2018.01); C12N 5/071 (2010.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C12N 15/635 (2013.01);
Abstract
A method of controlling the number of cells in a population of cells having silenced transcription of a target nucleic acid as a function of time includes recruiting a chromatin regulator (CR) to a site proximal to a transcription initiation site of the target nucleic acid to form a fraction of silenced cells in the population of cells. The chromatin regulator may be EED, KRAB, DNMT3, HDAC4, EZH2, REST, or a combination thereof.