The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Apr. 26, 2019
Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems
Decibel Therapeutics, Inc., Boston, MA (US);
Joseph Burns, Newton, MA (US);
Kathryn Ellis, Arlington, MA (US);
Adam Palermo, Cambridge, MA (US);
Martin Schwander, Auburndale, MA (US);
Jonathon Whitton, Cambridge, MA (US);
Decibel Therapeutics, Inc., Boston, MA (US);
Abstract
The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with mutations in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF protein. These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss.