The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2023
Filed:
Nov. 27, 2018
Egis Gyogyszergyar Zrt., Budapest, HU;
Gábor Berecz, Budapest, HU;
Bálint Nyulasi, Budapest, HU;
Mátyás Milen, Budapest, HU;
Gyula Simig, Budapest, HU;
András Mravik, Budapest, HU;
Gábor Németh, Budapest, HU;
Adrienn Keszthelyi, Budapest, HU;
Beatrix Bali, Budapest, HU;
Balázs Volk, Budapest, HU;
László Szlávik, Budapest, HU;
Zoltán Varga, Budapest, HU;
Daniel Ulej, Budapest, HU;
EGIS GYOGYSZERGYAR ZRT., Budapest, HU;
Abstract
Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4'-fluoro butyrophenone (X=I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.