The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 16, 2023

Filed:

Oct. 23, 2019
Applicant:

Yale University, New Haven, CT (US);

Inventors:

Farren Isaacs, Stamford, CT (US);

Miriam Amiram, Stamford, CT (US);

Adrian Haimovich, New Haven, CT (US);

Dieter Soil, Guilford, CT (US);

Assignee:

YALE UNIVERSITY, New Haven, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/93 (2013.01); C12N 15/102 (2013.01); C12N 15/1058 (2013.01); C12Y 601/01 (2013.01);
Abstract

Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and method can be used to produce recombinant proteins at a greater yield than the same or similar polypeptides made using conventional compositions, systems, and methods. Accordingly, in some embodiments, the polypeptides are ones that could not be made using conventional methods and reagents, or could not be made a sufficient yield or purity to serve a practical purpose using conventional methods and reagents. Polypeptides made using the disclosed compositions, systems, and methods are also provided.


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