The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Aug. 01, 2018
Exiris S.r.l., Rome, IT;
Paola Gallinari, Rome, IT;
Chantal Paolini, Rome, IT;
Gessica Filocamo, Rome, IL;
Mirko Brunetti, Rome, IT;
Armin Lahm, Rome, IT;
Hans-Friedrich Grunert, Freiburg, DE;
John Thompson, Sasbach, DE;
Lucia Ricci-Vitiani, Rome, IT;
Mauro Biffoni, Rome, IT;
EXIRIS S.R.L., Rome, IT;
Abstract
The present disclosure relates to monoclonal antibodies anti-FGFR4 and their use as medicaments and diagnostic agents. In particular, it relates to an antibody which specifically binds to the acid box domain of FGFR4 and to specific portions thereof. Nucleic acids coding for said antibody, vectors and host cells for their expression and production, antibody-drug conjugates and pharmaceutical compositions comprising said antibody are also within the scope of the present disclosure. The present disclosure also relates to antibodies anti-FGFR4 for use for detecting, killing, affecting or inhibiting development and/or differentiation of colon cancer stem cells.