The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Apr. 28, 2017
Applicant:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Inventors:
Scott A. Rivkees, Gainesville, FL (US);
Christopher Wendler, Gainesville, FL (US);
Lung-Ji Chang, Gainesville, FL (US);
Assignee:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C12N 5/16 (2006.01); A61K 48/00 (2006.01); C12N 9/64 (2006.01); C12N 15/86 (2006.01); A61P 35/00 (2006.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
C07K 16/2869 (2013.01); A61K 35/17 (2013.01); A61K 48/005 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70596 (2013.01); C12N 5/16 (2013.01); C12N 9/6472 (2013.01); C12N 15/86 (2013.01); C12Y 304/22062 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/70 (2013.01); C12N 2740/16043 (2013.01);
Abstract
Aspects of the disclosure relate to chimeric antigen receptors (CARs) comprising an antigen binding domain (e.g., anti-TSHR), transmembrane domain (e.g., CD28), and a cytoplasmic domain (e.g., CD27, CD-137, etc.) and a safety mechanism comprising an inducible apoptosis trigger. In some aspects, the disclosure relates to use of the CARs in T cells, compositions, kits and methods for the treatment of thyroid cancers.