logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11618911 B1

PDFFull Text
Date of Patent:
Apr. 04, 2023

Filed:

Jun. 02, 2022

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Applicant:

Codexis, Inc., Redwood City, CA (US);

Inventors:

Haibin Chen, Beijing, CN;

Steven J. Collier, Concord, MA (US);

Jovana Nazor, Milpitas, CA (US);

Joly Sukumaran, Singapore, SG;

Derek Smith, Singapore, SG;

Jeffrey C. Moore, Westfield, NJ (US);

Gregory Hughes, Scotch Plains, NJ (US);

Jacob Janey, New York, NY (US);

Gjalt W. Huisman, Redwood City, CA (US);

Scott J. Novick, Palo Alto, CA (US);

Nicholas J. Agard, San Francisco, CA (US);

Oscar Alvizo, Fremont, CA (US);

Gregory A. Cope, Menlo Park, CA (US);

Wan Lin Yeo, Singapore, SG;

Stefanie Ng Minor, Redwood City, CA (US);

Assignee:

Codexis, Inc., Redwood City, CA (US);

Attorney:

Codexis, Inc.

Primary Examiner:

Delia M Ramirez

Int. Cl.
CPC ...
C12N 9/06 (2006.01); C12P 13/02 (2006.01); C12P 13/00 (2006.01); C12P 17/18 (2006.01); C12P 13/04 (2006.01); C12P 13/06 (2006.01); C12P 17/10 (2006.01); C12P 17/12 (2006.01); C12P 17/16 (2006.01);
U.S. Cl.
CPC ...
C12P 13/02 (2013.01); C12N 9/0028 (2013.01); C12P 13/001 (2013.01); C12P 13/04 (2013.01); C12P 13/06 (2013.01); C12P 17/10 (2013.01); C12P 17/12 (2013.01); C12P 17/165 (2013.01); C12P 17/185 (2013.01); C12P 17/188 (2013.01); C12Y 105/01 (2013.01); C12Y 105/01023 (2013.01); C12Y 105/01024 (2013.01); C12Y 105/01028 (2013.01); Y02P 20/52 (2015.11);
Abstract

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Find Patent Forward Citations

Loading…