The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 04, 2023

Filed:

Jan. 24, 2019
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Scott Hunter Watterson, Pennington, NJ (US);

Murugaiah Andappan Murugaiah Subbaiah, Hosur, IN;

Carolyn Diane Dzierba, Middletown, CT (US);

Hua Gong, King of Prussia, PA (US);

Jason M. Guernon, Pipersville, PA (US);

Junqing Guo, Princeton, NJ (US);

Amy C. Hart, Ewing, NJ (US);

Guanglin Luo, Madison, CT (US);

John E. Macor, Washington Crossing, PA (US);

William J. Pitts, Newtown, PA (US);

Jianliang Shi, Furlong, PA (US);

Brian Lee Venables, Durham, CT (US);

Carolyn A. Weigelt, Langhorne, PA (US);

Yong-Jin Wu, Madison, CT (US);

Zhizhen Barbara Zheng, Cheshire, CT (US);

Sing-Yuen Sit, Meriden, CT (US);

Jie Chen, Cambridge, MA (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/53 (2006.01); C07D 253/08 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01);
Abstract

The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.


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