The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Apr. 08, 2020
Sanofi, Paris, FR;
Christian Beil, Frankfurt am Main, DE;
Jochen Beninga, Frankfurt am Main, DE;
Joerg Birkenfeld, Frankfurt am Main, DE;
Gary J. Nabel, Cambridge, MA (US);
Huawei Qiu, Westborough, MA (US);
Ercole Rao, Morfelden-Walldorf, DE;
Joerg Regula, Munich, DE;
Edward Seung, Cambridge, MA (US);
Ronnie Wei, Needman, MA (US);
Lan Wu, Cambridge, MA (US);
Zhen Xing, Cambridge, MA (US);
Ling Xu, Cambridge, MA (US);
Zhi-Yong Yang, Cambridge, MA (US);
Béatrice Cameron, Paris, FR;
Tarik Dabdoubi, Paris, FR;
Cendrine Lemoine, Paris, FR;
Catherine Prades, Paris, FR;
SANOFI, Paris, FR;
Abstract
Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.