The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2023
Filed:
Jan. 27, 2020
Applicant:
Harpoon Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Holger Wesche, San Francisco, CA (US);
Bryan D. Lemon, Mountain View, CA (US);
Richard J. Austin, San Francisco, CA (US);
Robert B. Dubridge, Belmont, CA (US);
Assignee:
HARPOON THERAPEUTICS, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61P 35/04 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61K 39/0011 (2013.01); A61P 35/04 (2018.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C07K 16/2809 (2013.01); C07K 16/30 (2013.01); A61K 2039/505 (2013.01); A61K 2039/55511 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/569 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
Disclosed herein are MSLN binding proteins with improved binding affinities and improved ability to mediate T cell dependent killing of cancer cells expressing mesothelin. Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of using such formulations are further provided.