The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2023
Filed:
Jan. 29, 2020
Oncternal Therapeutics, Inc, San Diego, CA (US);
University of Tennessee Research Foundation, Knoxville, TN (US);
Ramesh Narayanan, Cordova, TN (US);
Duane D. Miller, Collierville, TN (US);
Thamarai Ponnusamy, Memphis, TN (US);
Dong-Jin Hwang, Arlington, TN (US);
Charles B. Duke, Memphis, TN (US);
Christopher C. Coss, Upper Arlington, OH (US);
Amanda Jones, Silver Spring, MI (US);
James T. Dalton, Ann Arbor, MI (US);
University of Tennessee Research Foundation, Knoxville, TN (US);
Abstract
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.