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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11572368 B1

PDFFull Text
Date of Patent:
Feb. 07, 2023

Filed:

Aug. 11, 2016

Inhibitors of histone deacetylase

Applicants:

The General Hospital Corporation, Boston, MA (US);

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Edward Holson, Newton, MA (US);

Florence Fevrier Wagner, Ashland, MA (US);

Michel Weiwer, Cambridge, MA (US);

Li-Huei Tsai, Cambridge, MA (US);

Stephen J. Haggarty, Gloucester, MA (US);

Yan-Ling Zhang, Lexington, MA (US);

Assignees:

The General Hospital Corporation, Boston, MA (US);

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Robert H Havlin

Int. Cl.
CPC ...
C07D 491/107 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 309/08 (2006.01); C07D 311/82 (2006.01); C07D 333/20 (2006.01); C07D 405/12 (2006.01); C07D 493/08 (2006.01); C07D 211/22 (2006.01); C07D 213/40 (2006.01); C07C 271/28 (2006.01); C07C 275/30 (2006.01); C07C 275/40 (2006.01); C07C 281/06 (2006.01); C07C 211/52 (2006.01); C07C 233/43 (2006.01); C07C 233/56 (2006.01); C07C 233/62 (2006.01); C07C 235/82 (2006.01); C07D 409/12 (2006.01); C07C 237/20 (2006.01); C07D 205/06 (2006.01); C07D 213/56 (2006.01); C07D 241/12 (2006.01); C07D 333/24 (2006.01); C07C 237/24 (2006.01); C07D 205/04 (2006.01); C07D 209/44 (2006.01); C07D 209/52 (2006.01); C07D 211/34 (2006.01); C07D 211/62 (2006.01); C07D 295/195 (2006.01); C07D 471/04 (2006.01); A61K 31/167 (2006.01); A61K 31/402 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/437 (2006.01); A61K 31/445 (2006.01); A61K 31/351 (2006.01); A61K 31/352 (2006.01); A61K 31/381 (2006.01); A61K 31/397 (2006.01); A61K 31/415 (2006.01); A61K 31/4178 (2006.01); A61K 31/439 (2006.01); A61K 31/4418 (2006.01); A61K 31/4433 (2006.01); A61K 31/4439 (2006.01); A61K 31/4535 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/4965 (2006.01); A61K 31/50 (2006.01); A61K 31/501 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); C07C 233/42 (2006.01); C07D 231/04 (2006.01); C07D 237/04 (2006.01); C07D 295/185 (2006.01); C07D 311/04 (2006.01); C07D 407/12 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01); C07D 491/08 (2006.01);
U.S. Cl.
CPC ...
C07D 491/107 (2013.01); A61K 31/167 (2013.01); A61K 31/351 (2013.01); A61K 31/352 (2013.01); A61K 31/381 (2013.01); A61K 31/397 (2013.01); A61K 31/402 (2013.01); A61K 31/403 (2013.01); A61K 31/4035 (2013.01); A61K 31/415 (2013.01); A61K 31/4178 (2013.01); A61K 31/437 (2013.01); A61K 31/439 (2013.01); A61K 31/445 (2013.01); A61K 31/4418 (2013.01); A61K 31/4433 (2013.01); A61K 31/4439 (2013.01); A61K 31/4535 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/4965 (2013.01); A61K 31/50 (2013.01); A61K 31/501 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); C07C 211/52 (2013.01); C07C 233/42 (2013.01); C07C 233/43 (2013.01); C07C 233/56 (2013.01); C07C 233/62 (2013.01); C07C 235/82 (2013.01); C07C 237/20 (2013.01); C07C 237/24 (2013.01); C07C 271/28 (2013.01); C07C 275/30 (2013.01); C07C 275/40 (2013.01); C07C 281/06 (2013.01); C07D 205/04 (2013.01); C07D 205/06 (2013.01); C07D 209/44 (2013.01); C07D 209/52 (2013.01); C07D 211/22 (2013.01); C07D 211/34 (2013.01); C07D 211/62 (2013.01); C07D 213/40 (2013.01); C07D 213/56 (2013.01); C07D 231/04 (2013.01); C07D 237/04 (2013.01); C07D 241/12 (2013.01); C07D 295/185 (2013.01); C07D 295/195 (2013.01); C07D 309/08 (2013.01); C07D 311/04 (2013.01); C07D 311/82 (2013.01); C07D 333/20 (2013.01); C07D 333/24 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 491/08 (2013.01); C07D 493/08 (2013.01); C07C 2601/02 (2017.05); C07C 2601/08 (2017.05); C07C 2601/10 (2017.05); C07C 2601/14 (2017.05); C07C 2601/16 (2017.05); C07C 2602/08 (2017.05); C07C 2602/50 (2017.05);
Abstract

The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R, R, R, Rand t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

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