The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2023
Filed:
May. 01, 2020
Applicant:
Children's Hospital Medical Center, Cincinnati, OH (US);
Inventors:
Nicolas Nassar, Cincinnati, OH (US);
William Seibel, Liberty Township, OH (US);
Anjelika Gasilina, Bethesda, MD (US);
Jose Cancelas, Cincinnati, OH (US);
Assignee:
Children's Hospital Medical Center, Cincinnati, OH (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/444 (2006.01); A61P 35/02 (2006.01); A61K 31/53 (2006.01);
U.S. Cl.
CPC ...
A61K 31/444 (2013.01); A61K 31/53 (2013.01); A61P 35/02 (2018.01);
Abstract
A small molecule compound IODVA1 has been found to have cellular inhibitory activity against several transformed cell lines including Ras-driven cells. IODVA1 decreases cell-cell and cell-extra cellular matrix interactions and reduces growth of Ras-driven tumors. Applicants also synthesized compound NIRA2 and showed in vitro and in vivo efficacy and potency against models of Ph+(BCR-ABL1) B-ALL and of colon adenocarcinoma xenografts.