The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Sep. 23, 2021
Applicant:
Agency for Science, Technology and Research (A*star), Singapore, SG;
Inventors:
Wei Hung, Singapore, SG;
Thomas Hugo Keller, Singapore, SG;
Wei Ling Wang, Singapore, SG;
Gang Wang, Singapore, SG;
Congbao Kang, Singapore, SG;
Assignee:
Agency for Science, Technology and Research (A*STAR), Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/14 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 495/14 (2013.01); C07D 519/00 (2013.01);
Abstract
There are provided new heterobifunctional agents designed to mediated formation of protein-protein dimers and promote ubiquitination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.