The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Aug. 30, 2021
Applicant:
The Center for Neurologic Study, La Jolla, CA (US);
Inventors:
Richard Alan Smith, La Jolla, CA (US);
Darryl C. Rideout, Milford, PA (US);
Kathleen J. Myers, Oceanside, CA (US);
Andrew Kawasaki, San Diego, CA (US);
Assignee:
Center for Neurologic Study, La Jolla, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/22 (2006.01); A61P 29/00 (2006.01); C07D 405/06 (2006.01);
U.S. Cl.
CPC ...
C07D 221/22 (2013.01); A61P 29/00 (2018.01); C07D 405/06 (2013.01);
Abstract
Substituted analogs of dextromethorphan (DM) are disclosed, which are shown to have substantial binding affinity at both NMDA and sigma-1 receptors, and which are degraded by human liver enzymes more slowly than dextromethorphan. The analogs are useful as alternatives to dextromethorphan, and can provide the same benefits without requiring co-administration of a cytochrome P-450 enzyme inhibitor.