The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2022
Filed:
Oct. 08, 2019
Applicant:
Sanofi, Paris, FR;
Inventors:
Lan Wu, Cambridge, MA (US);
Ling Xu, Cambridge, MA (US);
Edward Seung, Cambridge, MA (US);
Ronnie Wei, Needham, MA (US);
Gary Nabel, Cambridge, MA (US);
Zhi-Yong Yang, Cambridge, MA (US);
Tarik Dabdoubi, Paris, FR;
Béatrice Cameron, Paris, FR;
Cendrine Lemoine, Paris, FR;
Catherine Prades, Paris, FR;
Assignee:
Sanofi, Paris, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 31/16 (2006.01); A61P 31/18 (2006.01); A61P 31/22 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 16/2818 (2013.01); A61P 31/16 (2018.01); A61P 31/18 (2018.01); A61P 31/22 (2018.01); C07K 16/2809 (2013.01); C07K 16/2896 (2013.01); C12N 5/0636 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01); C12N 2501/998 (2013.01);
Abstract
The disclosure provides methods of treating viral infection using trispecific binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind a CD38 polypeptide (e.g., human and/or cynomolgus monkey CD38 polypeptides), a CD28 polypeptide, and a CD3 polypeptide.