The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Apr. 09, 2019
Vanderbilt University, Nashville, TN (US);
Charles David Weaver, Nashville, TN (US);
Brendan F. Dutter, Nashville, TN (US);
Gary A. Sulikowski, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tlflux assays. The fluorescent thallium ion sensor compounds have a rhodol fluorophore attached to an amino dicarboxylic acid metal binding moiety. The compounds are prepared in the 'pro-dye' form, with the rhodol oxygen and the carboxylic acids of the metal binding unit masked by protecting groups. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos.
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