The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Dec. 09, 2019
The Regents of the University of California, Oakland, CA (US);
Abraham P. Lee, Irvine, CA (US);
Gopakumar Kamalakshakurup, Irvine, CA (US);
Mohammad Aghaamoo, Irvine, CA (US);
Xuan Li, Irvine, CA (US);
Gisela Lin, Irvine, CA (US);
Xuhao Luo, Irvine, CA (US);
Marzieh Ataei, Irvine, CA (US);
Michelle A. Digman, Irvine, CA (US);
Francesco Palomba, Irvine, CA (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Abstract
A passive, hydrodynamic technique implemented using a microfluidic device to perform co-encapsulation of samples in droplets and sorting of said droplets is described herein. The hydrodynamic technique utilizes laminar flows and high shear liquid-liquid interfaces at a microfluidic junction to encapsulate samples in the droplets. A sorting mechanism is implemented to separate sample droplets from empty droplets. This technique can achieve a one-one-one encapsulation efficiency of about 80% and can significantly improve the droplet sequencing and related applications in single cell genomics and proteomics.