The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Apr. 03, 2018
The United States of Americans Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
The University of North Carolina AT Charlotte, Charlotte, NC (US);
Bruce Allen Shapiro, Gaithersburg, MD (US);
Kirill Andreevich Afonin, Charlotte, NC (US);
Eckart H. U. Bindewald, Frederick, MD (US);
Mathias D. Viard, Frederick, MD (US);
Wojciech Kasprzak, Frederick, MD (US);
Marina A. Dobrovolskaia, Frederick, MD (US);
Justin R. Halman, Charlotte, NC (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
The University of North Carolina at Charlote, Charlotte, NC (US);
Abstract
The description provides a molecular switch comprising at least two nanoparticles, wherein a first nanoparticle comprises DNA and/or RNA oligonucleotides, and a second nanoparticle which is complementary to the first nanoparticle comprises reverse complementary DNA and/or RNA oligonucleotides of the first nanoparticle; wherein the complementary nanoparticles interact under physiological conditions leading to thermodynamically driven conformational changes in the first and second nanoparticles leading to their re-association to release one or more duplexes comprising said DNA and/or RNA oligonucleotides and the reverse complementary DNA and/or RNA oligonucleotides, and wherein the nanoparticles are not rings and have no single stranded toeholds.