The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 29, 2022

Filed:

Sep. 30, 2016
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Ambrx, Inc., La Jolla, CA (US);

Inventors:

Philip E. Brandish, Needham, MA (US);

Robert M. Garbaccio, Lansdale, PA (US);

Jeffrey Kern, Gilbertsville, PA (US);

Linda Liang, Mountain View, CA (US);

Sanjiv Shah, Wakefield, MA (US);

Dennis Zaller, Boston, MA (US);

Andrew Beck, San Diego, CA (US);

Dennis Gately, San Diego, CA (US);

Nick Knudsen, Escondido, CA (US);

Anthony Manibusan, San Diego, CA (US);

Jianing Wang, San Diego, CA (US);

Ying Sun, San Diego, CA (US);

Assignees:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Ambrx, Inc., La Jolla, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/28 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6889 (2017.08); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); C07K 16/2833 (2013.01); C07K 16/2896 (2013.01); A61K 45/06 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/565 (2013.01);
Abstract

Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.


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