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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11510937 B1

PDFFull Text
Date of Patent:
Nov. 29, 2022

Filed:

Aug. 14, 2019

Cftr mrna compositions and related methods and uses

Applicants:

Translate Bio, Inc., Lexington, MA (US);

Ethris Gmbh, Planegg, DE;

Inventors:

Michael Heartlein, Cambridge, MA (US);

Braydon Charles Guild, Concord, MA (US);

Frank DeRosa, Cambridge, MA (US);

Carsten Rudolph, Planegg, DE;

Christian Plank, Planegg, DE;

Lianne Smith, Cambridge, MA (US);

Assignees:

Translate Bio, Inc., Lexington, MA (US);

Ethris GmbH, Planegg, DE;

Attorneys:

Proskauer Rose LLP

Fangli Chen

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
A61K 31/713 (2006.01); C07H 21/04 (2006.01); A61K 31/7105 (2006.01); A61K 48/00 (2006.01); A61K 31/7115 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61K 47/69 (2017.01); C07K 14/705 (2006.01); A61K 9/127 (2006.01); C12N 9/14 (2006.01); C12N 15/63 (2006.01); C07H 21/02 (2006.01); C07K 14/47 (2006.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 9/0073 (2013.01); A61K 9/0078 (2013.01); A61K 9/1271 (2013.01); A61K 9/5123 (2013.01); A61K 31/7105 (2013.01); A61K 31/7115 (2013.01); A61K 47/6935 (2017.08); A61K 48/005 (2013.01); C07K 14/705 (2013.01); C12N 9/14 (2013.01); A61K 9/127 (2013.01); A61K 48/00 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C07K 14/4712 (2013.01); C12N 15/63 (2013.01); C12N 15/88 (2013.01); C12Y 306/03049 (2013.01);
Abstract

The present disclosure relates to materials, formulations, production methods, and methods for delivery of CFTR mRNA, including but not limited to chemically modified mRNA for induction of CFTR expression, including in the mammalian lung. The present invention is particularly useful for treating cystic fibrosis, but is also useful in the treatment of diseases related to CFTR gene.

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Heartlein, Michael. (2022). Cftr mrna compositions and related methods and uses (U.S. Patent No. 11510937). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11510937

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