The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2022
Filed:
Apr. 06, 2018
Kookmin University Industry Academy Cooperation Foundation, Seoul, KR;
Osong Medical Innovation Foundation, Chungcheongbuk-do, KR;
Sang Taek Jung, Gyeonggi-do, KR;
Sanghwan Ko, Seoul, KR;
Tae Gyu Lee, Seoul, KR;
So Young Choi, Sejong-si, KR;
Soo Han Lee, Seoul, KR;
Myung Ho Sohn, Sejong-si, KR;
Su Jin Kim, Chungcheongbuk-do, KR;
So Ra Park, Chungcheongbuk-do, KR;
Jong Shik Park, Sejong-si, KR;
Ju Hyeon Lim, Sejong-si, KR;
KOOKMIN UNIVERSITY INDUSTRY ACADEMY, Seoul, KR;
OSONG MEDICAL INNOVATION FOUNDATION, Chungcheongbuk-Do, KR;
Abstract
The present invention relates to a polypeptide including an Fc variant produced by substituting a portion of the amino acid sequence of the Fc domain of a human antibody with a different amino acid sequence. The present invention also relates to an antibody including the polypeptide. The Fc variant can find application in a wide range of antibodies and Fc-fusion constructs. In one aspect, the antibody or Fc fusion construct of the present invention is a therapeutic, diagnostic or laboratory reagent, preferably a therapeutic reagent. The Fc variant is suitable for use in the treatment of cancer because its in vivo half-life can be maximized by optimization of the portion of the amino acid sequence. The antibody or Fc fusion construct of the present invention is used to kill target cells that bear a target antigen, for example cancer cells. Alternatively, the antibody or Fc fusion construct of the present invention is used to block, antagonize or agonize a target antigen. For example, the antibody or Fc fusion construct of the present invention may be used to antagonize a cytokine or a cytokine receptor.