The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2022
Filed:
Dec. 23, 2020
Joseph M. Fox, Landenberg, PA (US);
Colin Thorpe, Newark, DE (US);
Amanda M. Tallon, Claymont, DE (US);
Yixin Xie, Newark, DE (US);
William Trout, Wilmington, DE (US);
Ashlyn S. Cantrel, Catasauqua, PA (US);
Julia E. Rosenberger, Wilmington, DE (US);
Joseph M. Fox, Landenberg, PA (US);
Colin Thorpe, Newark, DE (US);
Amanda M. Tallon, Claymont, DE (US);
Yixin Xie, Newark, DE (US);
William Trout, Wilmington, DE (US);
Ashlyn S. Cantrel, Catasauqua, PA (US);
Julia E. Rosenberger, Wilmington, DE (US);
University of Delaware, Newark, DE (US);
Abstract
A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein the dihydrotetrazine 1 comprises a first R group and a second R group, wherein the first R group is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the second R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, and heteroatom-containing groups; wherein the method comprises (a) providing the dihydrotetrazine 1 in a reaction medium, and (b) adding an enzyme as a catalyst and an oxidant to the reaction medium, whereby the dihydrotetrazine 1 is converted to the tetrazine 2.