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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11479770 B1

PDFFull Text
Date of Patent:
Oct. 25, 2022

Filed:

Oct. 05, 2018

Use of p38 inhibitors to reduce expression of dux4

Applicant:

Fulcrum Therapeutics, Inc., Cambridge, MA (US);

Inventors:

Angela Marie Cacace, Haddam Neck, CT (US);

Luis Gustavo Alejandro Rojas Soto, Cambridge, MA (US);

Lorin A. Thompson, III, Cohasset, MA (US);

Owen Brendan Wallace, Brookline, MA (US);

Lucienne V. Ronco, Wellesley, MA (US);

Ning Shen, Cambridge, MA (US);

Alan Scott Robertson, Cambridge, MA (US);

Aaron Nakwon Chang, Lexington, MA (US);

Assignee:

Fulcrum Therapeutics, Inc., Cambridge, MA (US);

Attorney:

Goodwin Procter LLP

Primary Examiner:

Jane J Zara

Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61P 21/00 (2006.01); A61K 31/4418 (2006.01); A61K 31/4439 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/416 (2006.01); A61K 31/437 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/513 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); C12Q 1/6827 (2018.01); C12Q 1/686 (2018.01); C12Q 1/6883 (2018.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/416 (2013.01); A61K 31/437 (2013.01); A61K 31/4418 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61P 21/00 (2018.01); C12Q 1/686 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6883 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/0073 (2013.01); A61K 45/06 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01);
Abstract

The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4. The present invention further relates to methods for treating patients suffering from diseases associated with increased expression of DUX4 or expression of an aberrant form of DUX4, such as Facioscapulohumeral muscular dystrophy (FSHD).

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