The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2022

Filed:

Jun. 05, 2018
Applicant:

Signalrx Pharmaceuticals, Inc., Omaha, NE (US);

Inventors:

Guillermo A. Morales, Oro Valley, AZ (US);

Joseph R. Garlich, Fort Collins, CO (US);

Donald L. Durden, Omaha, NE (US);

Assignee:

SignalRx Pharmaceuticals, Inc., Cumming, GA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/04 (2006.01); C07D 493/04 (2006.01); C07D 519/00 (2006.01); A61P 27/00 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 37/00 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); A61P 27/00 (2018.01); A61P 29/00 (2018.01); A61P 35/04 (2018.01); A61P 37/00 (2018.01); C07D 493/04 (2013.01); C07D 519/00 (2013.01); A61K 45/06 (2013.01);
Abstract

The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral, bacterial or fungal infection, atherosclerosis, Type 1 or 2 diabetes, obesity, inflammatory disease, and/or SYK-associated disorder including by modulating biological processes through the inhibition of SYK alone, or in combination with inhibition of one or more of PI3 kinase including PI3K-gamma isoform, BET bromodomain proteins, CDK 4/6, and checkpoint proteins, comprising the administration of a compound(s) of Formula I-V (or pharmaceutically acceptable salts thereof) as defined herein.


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