The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2022

Filed:

Jan. 07, 2022
Applicants:

Syz Cell Therapy Co., Guangdong, CN;

Hryz (Shenzhen) Biotech Co., Guangdong, CN;

Inventors:

Xiangjun Zhou, Shenzhen, CN;

Yanyan Han, Shenzhen, CN;

Xihe Chen, Shenzhen, CN;

Xiaoling Liang, Shenzhen, CN;

Assignees:

SYZ Cell Therapy Co., Shenzhen, CN;

HRYZ (Shenzhen) Biotech Co., Shenzhen, CN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61P 35/00 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 39/001157 (2018.08); A61K 39/001149 (2018.08); A61K 39/001153 (2018.08); A61K 39/001186 (2018.08); A61P 35/00 (2018.01); C12N 5/0636 (2013.01); A61K 2039/5158 (2013.01); C12N 2501/24 (2013.01); C12N 2501/515 (2013.01); C12N 2502/1121 (2013.01);
Abstract

The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.


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