The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Jan. 16, 2020
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Meghan Drummond Samuelson, Katonah, NY (US);
Brian Zambrowicz, Sleepy Hollow, NY (US);
Ka-Man Venus Lai, San Francisco, CA (US);
Charleen Hunt, Dumont, NJ (US);
Susannah Brydges, Putnam Valley, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Claudia Gonzaga-Jauregui, Elmsford, NY (US);
Jose Rojas, Newburgh, NY (US);
Nicole Alessandri-Haber, Rye Brook, NY (US);
Robert Breese, Patterson, NY (US);
Susan D. Croll, Putnam Valley, NY (US);
Regeneran Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.