The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2022
Filed:
Nov. 01, 2021
Applicant:
A-alpha Bio, Inc., Seattle, WA (US);
Inventors:
David Younger, Seattle, WA (US);
Randolph Lopez, Seattle, WA (US);
Arpita Sen, Seattle, WA (US);
Ryan Emerson, Seattle, WA (US);
Assignee:
A-ALPHA BIO, INC., Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 1/16 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C12N 1/16 (2013.01); C12N 15/1089 (2013.01);
Abstract
Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.