The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2022
Filed:
Feb. 26, 2020
Applicant:
Novartis Ag, Basel, CH;
Inventors:
David Barnes-Seeman, Cambridge, MA (US);
Scott Louis Cohen, Burlington, MA (US);
John Louis Diener, Cambridge, MA (US);
Christian Gampe, Watertown, MA (US);
James Roache, Cambridge, MA (US);
Amy White, Somerville, MA (US);
Sarah Louise Williams, Livermore, CA (US);
Jun Yuan, Boston, MA (US);
Frederic Zecri, Brookline, MA (US);
Assignee:
NOVARTIS AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07F 9/6561 (2006.01); C07H 19/167 (2006.01); C07H 19/207 (2006.01); C07K 14/575 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C07F 9/65616 (2013.01); C07H 19/167 (2013.01); C07H 19/207 (2013.01); C07K 14/5759 (2013.01);
Abstract
The disclosure relates to nucleic acids that contain modifications at the 5'-end, 3′-end or 5′-end and 3′-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.