The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Oct. 25, 2017
Grail, Inc., Menlo Park, CA (US);
The Chinese University of Hong Kong, Hong Kong, CN;
Eugeni Namsaraev, Palo Alto, CA (US);
Yuk-Ming Dennis Lo, Hong Kong, CN;
Rossa Wai Kwun Chiu, Hong Kong, CN;
Kwan Chee Chan, Hong Kong, CN;
Peiyong Jiang, Hong Kong, CN;
Kun Sun, Hong Kong, CN;
Wai Kei Lam, Hong Kong, CN;
The Chinese University of Hong Kong, Shatin, HK;
GRAIL, Inc., Menlo Park, CA (US);
Abstract
Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples. Various embodiments are directed to applications (e.g., diagnostic applications) of the analysis of the fragmentation patterns and size of cell-free DNA, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, including viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).